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Endometrial receptivity analysis (ERA)

endometrial receptivity

The Endometrial Receptivity Analysis(ERA) is a diagnostic test that helps evaluate a woman’s endometrial receptivity from a molecular perspective

An endometrium (the lining of the womb) is receptive when it is ready for the embryo implantation. Typically, this occurs around days 19-21 in each menstrual cycle of a fertile woman. This period of receptivity is what we call the window of implantation.

Lack of synchronisation between the embryo and endometrial receptivity is one of the causes of recurring implantation failure. This is why it is imperative to assess the endometrium in order to determine the optimal day for embryo transfer.

The ERA test reveals the personalised window of implantation (WOI) of each woman.This information will enablea personalised embryo transfer (pET), synchronising endometrial receptivity with the development of the embryo prepared for implantation. Thus increasing your chances of a successful embryo transfer.

Technique

ERA test is performed using a biopsy taken from the endometrium. It is a simple procedure that can be performed in the clinic without sedation. The ERA test is done in the preceding (mock) cycle to embryo transfer.

The biopsy process serves a dual purpose because it causes a local injury to the endometrium. Hence, it can act as the endometrial scratch at the same time.

Who is the ERA test recommended for?

The ERA test is recommended for patients experiencing repeated implantation failure with good quality embryos. This test is recommended for patients with a seemingly normal uterus, in which no other pathology has been detected.

In order to get pregnant good quality endometrium and a good quality embryo(s) are needed. This is the first test to test endometrium directly.

References

  1. Endometrial receptivity array: Clinical application͟, Mahajan N., J Hum Repr Sci. (2015, 8(3):121-9)
  2. Clinical management of endometrial receptivity͟, Blesa D et al., Semin Repr Med. (2014;32(5):410-3)
  3. Profiling the gene signature of endometrial receptivity: clinical results͟, Garrido-Gómez T et al. Fert Ster (2013;99(4):1078-85)
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