Other conditions that are commonly checked are sex chromosome linked conditions such as Klinefelter syndrome and Turner syndrome. (Please speak to your consultant for further details on this). The tests do not assess risk for mosaicism, partial trisomies or translocations. These tests may be performed as early as 10 weeks of pregnancy. These tests will provide accurate answers when they matter most — simply, safely, sooner.
Your baby’s cell free DNA can be detected circulating in your blood and so it requires a simple blood test, which is sent to the lab, analysed and the results returned within one week. The test uses DNA sequencing to count the number of copies of all chromosomes, and then uses a calculation method to determine if there are too many or too few copies of chromosomes 13,18, 21, X, Y present in your fetus.
You will also be required to have an ultrasound scan prior to the blood test to check the viability of your pregnancy.
NIPT can be performed for most pregnancies including IVF, singleton and twins. It can be performed on women who have conceived via assisted reproductive technology (ART) including use of a donor egg.
Although the tests are not 100% conclusive*, they are highly accurate.
The tests identify, in singleton pregnancies: more than 99% of fetuses with Trisomy 21; 98% of fetuses with Trisomy 18; 98% of fetuses with Trisomy 13; and 95% of fetuses with Turner Syndrome. X and Y analysis provides >99% accuracy for fetal sex. Accuracy for detecting other sex chromosome anomalies varies by condition.
The risk of requiring further testing such as CVS or Amniocentesis after an NIPT test is dramatically reduced
NIPT tests are able to deliver a much higher accuracy than other prenatal tests, such as Nuchal translucency or quadruple blood tests, giving you greater peace of mind. It’s totally non-invasive, posing minimal risk to mother or baby, can test for more than just Down Syndrome, and can be carried out as early as 10 weeks’ pregnant. NHS Down Syndrome screening tests are typically undertaken via a nuchal translucency ultrasound between 11 and 14 weeks. This can only estimate the risk of your baby having Down’s, it can’t tell you for sure either way. For example, if your result is one in 1,000, this means that for every 1,000 babies with your level of risk, one will have Down’s syndrome. A risk of one in 150 or less is considered high. If for some reason the scan cannot be completed, expectant mothers are offered a blood test between 14 and 20 weeks of pregnancy, which is less accurate than the nuchal test. Further testing such as CVS and amniocentesis are invasive and have risk factors associated with them.
Harley Street Fertility Clinic offers two non-invasive prenatal testing options:
Both of these tests have been clinically validated to a very high standard and provide some of the lowest test failure rates of all NIPTs currently available, which is why we have chosen to offer them.
Please speak to our nursing team for more information on test options, turnaround times and pricing.