Losing a pregnancy is one of the most painful experiences a person can go through. When it happens, it is natural to want answers, and to want to understand whether there is a medical explanation that might affect future pregnancies.
SABSCAN is a non-invasive blood test that can help identify potential genetic causes of pregnancy loss. It works by detecting cell-free fetal DNA in the mother’s bloodstream, which is released during pregnancy and remains present for a short time after loss. By analysing this DNA, SABSCAN can screen for chromosomal abnormalities, which are among the most common reasons a pregnancy does not continue. Research suggests chromosomal factors may be responsible for up to 70% of pregnancy losses.
Who is SABSCAN for?
SABSCAN may be appropriate if you have recently experienced a miscarriage and want to explore whether a chromosomal cause can be identified. It is particularly relevant in situations where:
-
Standard tissue testing (known as POC, or products of conception analysis) has not been possible, for example because tissue was unavailable or the results were inconclusive
-
Tissue contamination affected the reliability of earlier testing, which can occur in up to one in four cases
-
You and your clinical team want a non-invasive alternative to surgical tissue collection
SABSCAN is not a diagnostic test and does not replace clinical assessment or consultation with your doctor. It is one part of a broader conversation about understanding your pregnancy history and planning next steps with confidence.
What does the test involve?
The process is straightforward. A blood sample is collected as soon as possible after pregnancy loss, ideally within 24 hours. The sample is processed in a specialist genetic laboratory, where cell-free fetal DNA is isolated and sequenced. Results are typically available within two weeks.
The test can detect changes in chromosome number, such as missing or additional chromosomes, as well as smaller structural changes including partial losses or duplications of chromosomal segments.
What happens after the results?
Your results will be reviewed with your doctor or consultant, who will explain what they mean in the context of your individual situation. Where a chromosomal abnormality is identified, this can provide important information to guide future treatment planning. Where no abnormality is found, that too is clinically meaningful and can help inform next steps.
Pricing and access
SABSCAN is available at HSFC at a cost of £700. If you have recently experienced a pregnancy loss and would like to discuss whether this test is right for you, please speak with your consultant or contact our patient care team who can advise on timing and next steps.
